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Research institution

Virginia Commonwealth University — Cen Lab

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The Cen Lab at Virginia Commonwealth University investigates new approaches to treating malaria by targeting enzymes that the parasite needs to survive.

0
Endemic countries
1
U.S. states
3
Products and programs
About

What they do

The Cen Lab at Virginia Commonwealth University investigates new approaches to treating malaria by targeting enzymes that the parasite needs to survive.1 Its research focuses on PfSir2A, which helps regulate parasite genes involved in immune evasion, and PfNic, which helps the parasite produce NAD+, a molecule essential for cellular metabolism.1 The lab develops and evaluates small-molecule inhibitors of both enzymes as potential antimalarial drugs.1 Its U.S. R&D is based in Richmond, Virginia, and the work is in the discovery stage.1

In the United States
Products and programs

In the field and in development

PfSir2A antimalarial inhibitor program3,1
PfNic / NAD+ biosynthesis inhibitor program1
2026 Quest Fund project, “Targeting NAD Biosynthesis in Malaria Parasites: A Novel Antiparasitic Strategy”1
Where they work

Partnerships

No endemic-country partnerships are listed.

U.S. partners

Who they work with in the United States

  • The Hormel Institute, University of Minnesota1
    Austin, MN
Sources

Where this comes from

  1. 1Confirmed by the organization
  2. 2drugdiscovery.vcu.edu
  3. 3scholarscompass.vcu.edu