InnovAtlasMalaria No More
Research institution

UCSF – Center for Malaria and Vector-Borne Diseases – Rosenthal Lab,

DiscoverDevelopDeliver

The Rosenthal laboratory studies malaria parasite biology, antimalarial drug resistance, and drug discovery, including basic research on parasite proteases as antimalarial drug targets, evaluating new compounds such as protease inhibitors and oxaboroles, and long-running field research in Uganda and Burkina Faso on drug efficacy, resistance, molecular epidemiology, and chemoprevention.

2
Endemic countries
1
U.S. states
5
Products and programs
About

What they do

The Rosenthal laboratory studies malaria parasite biology, antimalarial drug resistance, and drug discovery, including basic research on parasite proteases as antimalarial drug targets, evaluating new compounds such as protease inhibitors and oxaboroles, and long-running field research in Uganda and Burkina Faso on drug efficacy, resistance, molecular epidemiology, and chemoprevention.1 Its U.S. R&D is based in San Francisco, California.1 This work spans the discovery, development, and delivery stages.1

In the United States
Products and programs

In the field and in development

Mechanisms of P. falciparum sensitivity to the antimalarial drug pipeline (NIH R01AI139179)3,1
Resistance to artemisinin-based combination therapies in Uganda (NIH R01AI075045)4,2,1
Pharmacological insights into antimalarial exposure and drug resistance (NIH R01AI117001)2,1
Optimal chemopreventive regimens in Uganda (NIH U01AI141308)2,1
IMMRSE-U genomic surveillance project (with Drs. Greenhouse, Briggs, and Conrad)1
Where they work

Partnerships in 2 endemic countries

ResearchSurveillance and genomics
  • Institut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso · Collaborative field research on malaria drug efficacy and resistance1
Uganda
Africa
  • Infectious Diseases Research Collaboration (IDRC) · Collaborative field research on antimalarial drug efficacy, resistance, and malaria epidemiology1
  • Uganda Ministry of Health · Malaria research and surveillance collaboration1
  • African Center of Excellence in Bioinformatics · Genomic surveillance and bioinformatics collaboration1
  • Makerere University · Malaria research collaboration1
U.S. partners

Who they work with in the United States

  • NIH/NIAID1
    Bethesda, MD · Funder · funder
  • Gates Foundation1
    Seattle, WA · Funder · funder
    In the atlas
Sources

Where this comes from

  1. 1Confirmed by the organization
  2. 2infectiousdiseases.ucsf.edu
  3. 3pubmed.ncbi.nlm.nih.gov
  4. 4pubmed.ncbi.nlm.nih.gov