Research institution

Portland State University and VA Portland Health Care System — T111 Antimalarial Program

Develop

Endemic countries

U.S. states

Products and programs

About

What they do

Researchers at Portland State University and the VA Portland Health Care System are developing T111 and its prodrugs as antimalarial medicines active against the blood, liver, dormant liver, and mosquito stages of the malaria parasite.¹ T111 is active against drug-resistant parasites, including artemisinin-resistant clinical isolates, and works through a mechanism distinct from current antimalarials.¹ The program's R&D is jointly based in Portland, Oregon, with in vivo blood-stage studies conducted at the VA.¹ The work is in the development stage, with T111 and its prodrugs in preclinical development.¹

In the United States

Portland, OR^2,1Research and development

Products and programs

In the field and in development

T111, lead multi-stage acridone antimalarial candidate^3,1

T111 prodrugs¹

Transmission-blocking acridone sugar-bait approach¹

Where they work

Partnerships in 2 endemic countries

Product testing

Rwanda

Africa

University of Rwanda and University Teaching Hospital of Butare, Huye · evaluation of T111 against artemisinin-resistant P. falciparum clinical isolates¹

Uganda

Africa

Infectious Diseases Research Collaboration, Kampala · ex vivo testing of T111 against P. falciparum clinical isolates¹

U.S. partners

Who they work with in the United States

Walter Reed Army Institute of Research^4,1
Silver Spring, MD
In the atlas
Oregon Health & Science University^4,1
Portland, OR
In the atlas
University of California, San Francisco^4,1
San Francisco, CA
University of Notre Dame^4,1
Notre Dame, IN
In the atlas
SRI International¹
Menlo Park, CA
Dominican University of California¹
San Rafael, CA
University of South Florida¹
Tampa, FL
In the atlas
Harvard T.H. Chan School of Public Health¹
Boston, MA
In the atlas
NIH/NIAID Division of Intramural Research¹
Rockville, MD
In the atlas
Howard Hughes Medical Institute¹
Boston, MA
In the atlas
NIH/NIAID^4,1
Bethesda, MD · Funder · funder
U.S. Department of Defense, CDMRP Peer Reviewed Medical Research Program¹
Funder · funder
In the atlas
U.S. Department of Veterans Affairs¹
Washington, DC · Funder · funder

Sources

Where this comes from

1Confirmed by the organization
2pdx.edu
3pdx.edu
4pdx.edu